Publications by authors named "O C Manintveld"
Article Synopsis
- Normothermic ex situ heart perfusion (ESHP) improves the availability of hearts from donors after circulatory death (DCD), but current methods for assessing heart function, like monitoring lactate levels, are not very effective.* -
- This study evaluated the use of high-resolution cardiac mapping during ESHP to analyze the electrical function of DCD hearts, revealing that lower voltages could indicate myocardial injury.* -
- The results from mapping ten DCD hearts showed that the technique is safe and feasible, and it could provide valuable insights into graft function for marginal donor hearts.*
Article Synopsis
- Normothermic heart perfusion (ESHP) allows for evaluating hearts from donors who experienced circulatory death, highlighting the need for sensitive metrics to gauge heart function before transplantation.* -
- This study introduces electrophysiological (EP) parameters as potential biomarkers for assessing post-ischemic heart performance, using porcine hearts categorized by different warm ischemia durations for analysis.* -
- Findings indicate that hearts affected by prolonged warm ischemia exhibit lower voltage and flatter potential slopes in electrical measurements, which correlate with their contractile performance and could assist in determining the viability of DCD hearts for transplantation.*
Complications like acute cellular rejection (ACR) and infection are known risk factors for the development of chronic lung allograft dysfunction, impacting long-term patient and graft survival after lung transplantation (LTx). Differentiating between complications remains challenging and time-sensitive, highlighting the need for accurate and rapid diagnostic modalities. We assessed the ability of exhaled breath analysis using an electronic nose (eNose) to distinguish between ACR, infection, and mechanical complications in LTx recipients (LTR) presenting with suspected complications.
View Article and Find Full Text PDFBackground: Right ventricular failure (RVF) is a significant cause of morbidity and mortality in patients with a left ventricular assist device (LVAD). This study is aimed to investigate the influence of a pectus excavatum on early and late outcomes, specifically RVF, following LVAD implantation.
Methods: A retrospective study was performed, that included patients with a HeartMate 3 LVAD at our tertiary referral center.
Background: Adding functional information by CT-derived fractional flow reserve (FFRct) to coronary CT angiography (CCTA) and assessing its temporal change may provide insight into the natural history and physiopathology of cardiac allograft vasculopathy (CAV) in heart transplantation (HTx) patients. We assessed FFRct changes as well as CAV progression over a 2-year period in HTx patients undergoing serial CT imaging.
Methods: HTx patients from Erasmus MC and Mount Sinai Hospital, who had consecutive CCTAs 2 years apart were evaluated.