Publications by authors named "O Bulgakova"
Background: Radon, a radioactive gas, is a significant risk factor for lung cancer, especially in non-smokers. This study examines the expression of exosomal microRNAs (miRNAs) as potential biomarkers for radon-induced effects.
Methods: A total of 109 participants from high- and low-radon areas in Kazakhstan were included.
Exposure to ionizing radiation can result in the development of a number of diseases, including cancer, cataracts and neurodegenerative pathologies. Certain occupational groups are exposed to both natural and artificial sources of radiation as a consequence of their professional activities. The development of non-invasive biomarkers to assess the risk of exposure to ionizing radiation for these groups is of great importance.
View Article and Find Full Text PDFThis review discusses the relationship between cellular senescence and radiation exposure. Given the wide range of ionizing radiation sources encountered by people in professional and medical spheres, as well as the influence of natural background radiation, the question of the effect of radiation on biological processes, particularly on aging processes, remains highly relevant. The parallel relationship between natural and radiation-induced cellular senescence reveals the common aspects underlying these processes.
View Article and Find Full Text PDFArticle Synopsis
- Type 2 diabetes mellitus (T2D) is a chronic condition marked by insulin resistance and dysfunction of β-cells, leading to various health complications.
- A study analyzed plasma samples from 44 T2D patients and 22 healthy individuals, revealing 229 miRNAs with significant expression differences, including increased levels of miR-5588-5p and decreased levels of miR-496 in T2D patients.
- The researchers also found that obesity affects miRNA expression, specifically miR-144-3p and miR-99a-5p, and identified key pathways related to chromatin modification and apoptosis linked to certain miRNAs.
Asbestos is a known carcinogen; however, the influence of chrysotile asbestos on the development of tumor-related diseases remains a subject of intense debate within the scientific community. To analyze the effect of asbestos, we conducted a study using the MRC5 cell line. We were able to demonstrate that chrysotile asbestos stimulated the production of reactive oxygen species (ROS), leading to cell death and DNA damage in the MRC5 cell line, using various techniques such as ROS measurement, comet assay, MTT assay, and qPCR.
View Article and Find Full Text PDF