Publications by authors named "O Bozdogan"
Article Synopsis
- A recent discovery links the ZFYVE19 mutation to non-syndromic cholestasis, characterized by high gamma-glutamyl transferase levels, and potentially causing neonatal and intrahepatic cholestasis.
- A 4-year-old patient with a confirmed ZFYVE19 mutation, diagnosed at age 2, showed elevated liver enzymes but maintained normal liver function; treatment with ursodeoxycholic acid effectively reduced symptoms.
- Continued monitoring and whole exome sequencing (WES) are recommended to further understand the mutation's effects and possible liver complications in similar cases of unexplained liver issues.
Ambiguous melanocytic lesions/tumors (AMLs) can be simply described as melanocytic neoplasms that cannot be differentiated as either a melanoma or a nevus. Preferentially expressed antigen in melanoma (PRAME) is a novel antibody that can help differentiate between nevi and melanomas. However, its usefulness remains controversial in AMLs.
View Article and Find Full Text PDFIt is well known that metastasis is the most crucial factor in determining the fate of the patient. The prognosis of melanoma is very poor at the stage of metastasis. Recently, several genes and proteins, including kindlin3, dioxin receptor (AhR), RASSF6, and claudin-11, which were shown as possible prognostic biomarkers for human tumours, were described.
View Article and Find Full Text PDFObjectives: This study aims to investigate whether plasma-rich plasma (PRP) enhances the osteogenic potential of periosteal grafts used to repair bone defects and maintains both histologically and biomechanically more durable bone tissue.
Materials And Methods: A standard bone defect was formed to the left femurs of 54 Sprague-Dawley rats and three groups were formed. In the first group (n=18), no periosteal repair was done for bone defect.
Aim: The aim of this study is to compare the differences between intensity-modulated radiotherapy (IMRT) and single-arc/partial-arc volumetric modulated arc therapy (SA/PA-VMAT) techniques in locally advanced-stage non-small cell lung cancer (NSCLC).
Materials And Methods: Locally advanced 22 patients with NSCLC were evaluated retrospectively. Each patient underwent radiation therapy with either IMRT or SA-VMAT or 2PA-VMAT technique.