Publications by authors named "O Bourron"
In patients with diabetes, peripheral arterial disease, particularly below the knee, is associated with medial arterial calcification. This is a frequent and potentially serious complication, affecting all types of diabetes. In recent years, our understanding of the pathophysiology and clinical significance of medial arterial calcification has improved considerably.
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- - Cardiometabolic disorders significantly contribute to cardiovascular diseases, with sphingosine-1-phosphate (S1P) and its receptors (S1PRs) playing crucial roles in maintaining heart health through complex signaling pathways.
- - S1P is transported in the bloodstream by carriers such as high-density lipoprotein and albumin, allowing it to influence various essential processes like cardiac contractility, inflammation, and angiogenesis.
- - The review highlights the roles of S1P/S1PRs in heart diseases and explores therapeutic potential, including the drug Fingolimod, while discussing the challenges of developing new treatments that target these receptors.
Aim: The use of vitamin K antagonists (VKAs) may increase the risk of peripheral arterial disease (PAD) because vitamin K is a strong inhibitor of medial arterial calcification. Type 2 diabetes (T2D) exposes patients to an increased risk of PAD. We examined how the use of VKAs modulates the risk of incident PAD in people with T2D.
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- This study investigates the link between non-alcoholic fatty liver disease (NAFLD) biomarkers and coronary artery calcification (CAC) in type 2 diabetes patients, emphasizing the potential for NAFLD biomarkers to enhance cardiovascular risk assessment.* -
- Researchers examined data from 617 patients with type 2 diabetes, using computed tomography to measure coronary artery calcium scores and FibroMax® panels from blood samples to evaluate liver conditions.* -
- Results showed a significant association between increasing FibroTest® stages and higher CAC scores, suggesting that NAFLD biomarkers can independently contribute to predicting cardiovascular risk beyond traditional factors.*
Article Synopsis
- - The study aimed to evaluate how the SINBAD score, which assesses factors like ischaemia and neuropathy, relates to major foot complications in diabetic patients with ulcers.
- - It included 537 patients from six hospitals, analyzing their SINBAD scores and tracking major adverse foot events over 5-6 months.
- - Results showed a clear connection between the SINBAD score and these adverse events, indicating that lower scores predict fewer complications, making the SINBAD score a valuable predictive tool.