Publications by authors named "O Boulat"
Purpose: While patients with early-stage Hodgkin lymphoma (HL) have an excellent outcome with combined treatment, the radiation therapy (RT) dose and treatment with chemotherapy alone remain questionable. This noninferiority trial evaluates the feasibility of reducing the dose or omitting RT after chemotherapy.
Methods And Materials: Patients with untreated supradiaphragmatic HL without risk factors (age ≥ 50 years, 4 to 5 nodal areas involved, mediastinum-thoracic ratio ≥ 0.
Introduction: High-sensitivity cardiac troponin assays have significantly improved the sensitivity of myocardial infarction detection by using cutoff values and early absolute changes. However, variation in repeated measures also depends on biological variability. This study aimed to assess the potential circadian component of this biological variability.
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- The hs-TnT assay is effective in helping doctors make decisions for low-risk patients with chest pain, though its reliability in this specific group has not been thoroughly documented.
- In a study involving 48 patients, the hs-TnT levels were measured at three different times to evaluate their ability to predict myocardial ischaemia detected by PET-CT.
- Results showed a strong negative predictive value (94% at T0, 100% at T2, and 100% at T6), indicating that low hs-TnT levels (<4 ng/L) can confidently rule out significant ischaemia, despite lower accuracy in identifying positive cases.
Aim: Several predictors of metastatic colorectal cancer (mCRC) outcomes have been described. Specific geriatric characteristics could be of interest to determine prognosis.
Method: Elderly patients (75+) with previously untreated mCRC were randomly assigned to receive infusional 5-fluorouracil-based chemotherapy, either alone (FU) or in combination with irinotecan (IRI).
Background: We elaborated a model that predicts the centiles of the 25(OH)D distribution taking into account seasonal variation.
Methods: Data from two Swiss population-based studies were used to generate (CoLaus) and validate (Bus Santé) the model. Serum 25(OH)D was measured by ultra high pressure LC-MS/MS and immunoassay.