Characterization of an Monofunctional Phosphomethylpyrimidine Kinase That Is Inhibited by Pyridoxal Phosphate.

Thiamin and its phosphate derivatives are ubiquitous molecules involved as essential cofactors in many cellular processes. The biosynthesis of thiamin employs the parallel synthesis of 4-methyl-5-(2-hydroxyethyl)thiazole (THZ-P) and 4-amino-2-methyl-5(diphosphooxymethyl) pyrimidine (HMP) pyrophosphate (HMP-PP), which are coupled to generate thiamin phosphate. Most organisms that can biosynthesize thiamin employ a kinase (HMPK or ThiD) to generate HMP-PP.

Comparison of Axillary versus Rectal Temperature Timing in Canine and Feline Patients.

Research on alternatives to rectal thermometry in canine and feline patients has focused on equipment and measurement location but not procedure duration. In a crossover clinical scenario, we evaluated the time prior to (Pre-TempT) and after (Post-TempT) rectal and axillary thermometry in a diverse demographic of canine ( = 114) and feline ( = 72) patients. Equipment duration was controlled to determine a presumptive total time (TTime) associated with each thermometry method.

Substituted 1,3,5-Triazine Hexacarboxylates as Potential Linkers for MOFs.

Hexacarboxylates are promising linkers for MOFs such as NU-109 or NU-110, which possess large values for surfaces and pore volumina. Starting from 2,4,6-tris(bromoaryl)-1,3,5-triazines, palladium-catalyzed cross coupling reactions (Suzuki-Miyaura, Sonogashira-Hagihara) form elongated hexacarboxylate linkers. Eight new 2,4,6-tris(biphenyl) and 2,4,6-tris(phenylethynylphenyl) 1,3,5-triazines have been prepared in quantities ranging from 40 mg to 1.

Synthesis, functionalisation and post-synthetic modification of bismuth metal-organic frameworks.

Two new bismuth metal-organic frameworks (Bi-MOFs) were discovered using high throughput experiments employing bismuth(iii) nitrate pentahydrate and triazine-2,4,6-triyl-tribenzoic acid (HTATB). The reaction was carried out for long reaction times (∼5 d) in a water/DMF-mixture and resulted in the formation of [Bi(O)(OH)(TATB)]·HO (denoted as CAU-35). By switching to short reaction times and a methanol/DMF-mixture as the solvent, an analogue of CAU-7-BTB with the composition [Bi(TATB)]·DMF·6HO (denoted as CAU-7-TATB) was obtained.

Elongated and substituted triazine-based tricarboxylic acid linkers for MOFs.

New triazine-based tricarboxylic acid linkers were prepared as elongated relatives of triazinetribenzoic acid (TATB). Additionally, functional groups (NO, NH, OMe, OH) were introduced for potential post-synthetic modification (PSM) of MOFs. Functionalized tris(4-bromoaryl)triazine "cores" (,) were obtained by unsymmetric trimerization mixing one equivalent of an acid chloride (OMe or NO substituted) with two equivalents of an unsubstituted nitrile.