Publications by authors named "O Berezovska"
Objective: Aim: To examine and analyze the state of vitamin and mineral homeostasis in children with recurrent respiratory diseases.
Patients And Methods: Materials and Methods: To achieve the goal, 62 children of primary school age with a diagnosis of Recurrent Respiratory diseases were examined in comparison with data of healthy children of the control group (n=26). The study included a clinical examination of children, determination of serum vitamin and mineral levels.
The recently discovered interaction between presenilin 1 (PS1), a subunit of γ-secretase involved in amyloid-β (Aβ) peptide production, and GLT-1, the major brain glutamate transporter (EAAT2 in the human), may link two pathological aspects of Alzheimer's disease: abnormal Aβ occurrence and neuronal network hyperactivity. In the current study, we employed a FRET-based fluorescence lifetime imaging microscopy (FLIM) to characterize the PS1/GLT-1 interaction in brain tissue from sporadic AD (sAD) patients. sAD brains showed significantly less PS1/GLT-1 interaction than those with frontotemporal lobar degeneration or non-demented controls.
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- * The study identifies a direct interaction between GLT-1 and Presenilin 1 (PS1), revealing that GLT-1 can lower amyloid-beta (Aβ) production by altering γ-secretase activity, thereby affecting how amyloid precursor protein (APP) is processed.
- * Targeting the GLT-1/PS1 interaction may serve as a promising new therapeutic approach to manage AD, as inhibiting this interaction increases Aβ levels, suggesting its critical role in disease progression.*
γ-Secretase plays a pivotal role in the central nervous system. Our recent development of genetically encoded Förster resonance energy transfer (FRET)-based biosensors has enabled the spatiotemporal recording of γ-secretase activity on a cell-by-cell basis in live neurons . Nevertheless, how γ-secretase activity is regulated remains unclear.
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- Previous experiments observed the effects of microgravity on fetal mouse long bones, and this study aimed to confirm those findings while examining the impact of daily 1×g exposure during microgravity on bone growth and mineralization.
- Two separate experiments were carried out on American and Russian space missions, using 17-day-old fetal mouse bones cultured for four days.
- Results revealed that microgravity reduced proteoglycan content and slowed mineralized bone growth, but daily exposure to 1×g for at least 6 hours helped mitigate these effects, suggesting artificial gravity could serve as an effective countermeasure.