Pediatric acral pigmentation related to a beetle contact.

We report a case of the appearance of dark pigmented skin on the plantar surface of the foot and toes in a young child, likely caused by the beetle Few such documented cases occur in the literature and none reported from our region. Identifying the cause is important to avoid unnecessary investigations and treatment, and to provide reassurance to patients.

Reconfigured single- and double-diode models for improved modelling of solar cells/modules.

Proper modeling of PV cells/modules through parameter identification based on the real current-voltage (I-V) data is important for the efficiency of PV systems. Most related works have concentrated on the classical single-diode model (SDM) and double-diode model (DDM) and their parameter extraction by various metaheuristic algorithms. In order to render more accurate and representative modeling, this paper adds a small resistance in series with the diodes in SDM and DDM.

Dual targeting of HSP90 and BCL-2 in breast cancer cells using inhibitors BIIB021 and ABT-263.

Purpose: The incidence of breast cancer has been increasing in recent years, and monotherapy approaches are not sufficient alone in the treatment of breast cancer. In the combined therapy approach, combining two or three different agents in lower doses can mitigate the side effects on living cells and tissues caused by high doses of chemical agents used alone. ABT-263 (navitoclax), a clinically tested Bcl-2 family protein inhibitor, has shown limited success in clinical trials due to the development of resistance to monotherapy in breast cancer cells.

Tricine-modified chitosan as a strategy for enhancing hydrophilicity and gene delivery.

In this study, we investigated the effect of chitosan modification with tricine on transfection efficiency by preserving its ability to form complexes with plasmid DNA (pDNA) and increasing its hydrophilicity. The inherent limitations of chitosan, such as poor solubility at physiological pH, insufficient cellular uptake, and strong ionic interactions with pDNA, typically result in low transfection efficiency. To overcome these challenges, Tricine, a hydrophilic molecule containing a secondary amine group, was conjugated to chitosan.