Impact of Conventional and Laser-Assisted Machining on the Microstructure and Mechanical Properties of Ti-Nb-Cr-V-Ni High-Entropy Alloy Fabricated with Directed Energy Deposition.

The high-entropy alloy (HEA) has recently attracted significant interest due to its novel alloy design concept and exceptional mechanical properties, which may exhibit either a single or multi-phase structure. Specifically, refractory high-entropy alloys (RHEA) composed of titanium, niobium, and nickel-based HEA demonstrate remarkable mechanical properties at elevated temperatures. Additive manufacturing (AM), specifically Direct Energy Deposition (DED), is efficient in fabricating high-entropy alloys (HEA) owing to its fast-cooling rates, which promote uniform microstructures and reduce defects.

Protective effects of Kaempferol on hepatic apoptosis via miR-26a-5p enhancement and regulation of TLR4/NF-κB and PKCδ in a rat model of nonalcoholic fatty liver.

This study aimed to evaluate kaempferol's, a dietary flavonoid widely present in plants, potential impact on nonalcoholic fatty liver disease (NAFLD) and its underlying mechanisms. In this study, 60 adult male rats were used and divided into a control group receiving a standard pellet diet, a kaempferol-treated group receiving kaempferol (250 mg/kg), a high-fat diet (HFD) group receiving HFD, and a kaempferol-treated HFD group. At the end of the experiment, the total lipid profile and liver enzymes were assayed in the serum.

A cell atlas foundation model for scalable search of similar human cells.

Single-cell RNA-seq (scRNA-seq) has profiled hundreds of millions of human cells across organs, diseases, development, and perturbations to date. Mining these growing atlases could reveal cell-disease associations, discover cell states in unexpected tissue contexts, and relate in vivo biology to in vitro models. These require a common measure of cell similarity across the body and an efficient way to search.

Effects of Mo Addition on Microstructure and Corrosion Resistance of CrCoNiFeMo High-Entropy Alloys via Directed Energy Deposition.

Highly entropy alloys (HEAs) are novel materials that have great potential for application in aerospace and marine engineering due to their superior mechanical properties and benefits over conventional materials. NiCrCoFe, also referred to as Ni-based HEA, has exceptional low-temperature strength and microstructural stability. However, HEAs have limited corrosion resistance in some environments, such as a 3.