Publications by authors named "O Bastien"

Betaine lipids (BL) are relatively understudied non‑phosphorus glycerolipids. They are predominantly found in algae but have also been detected in other unicellular eukaryotes, fungi, bacteria, and some bryophytes and pteridophytes. These extraplastidial lipids are considered as substitute for phospholipids in organisms, particularly under phosphate (Pi) deficiency.

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VPS13 is a lipid transfer protein family conserved among Eukaryotes and playing roles in fundamental processes involving vesicular transport and membrane expansion including autophagy and organelle biogenesis. VPS13 folds into a long hydrophobic tunnel, allowing lipid transport, decorated by distinct domains involved in protein localization and regulation. Whereas VPS13 organization and function have been extensively studied in yeast and mammals, information in organisms originating from primary endosymbiosis is scarce.

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Article Synopsis
  • Many organisms adapt to nutrient limitations by altering their lipid compositions; for instance, microalgae substitute phospholipids with betaine lipids during phosphate starvation, while higher plants resort to glycolipids.
  • This study compares the physicochemical properties of two types of lipids: dipalmitoylphosphatidylcholine (DPPC) and dipalmitoyl-diacylglyceryl-N,N,N-trimethylhomoserine (DP-DGTS), revealing that DP-DGTS bilayers are thicker and more rigid than DPPC bilayers and have unique electrostatic properties.
  • The findings help explain the diversity of betaine lipids in marine organisms and the absence of these lipids in seed plants, highlighting
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Photoautotrophs' environmental responses have been extensively studied at the organism and ecosystem level. However, less is known about their photosynthesis at the single-cell level. This information is needed to understand photosynthetic acclimation processes, as light changes as it penetrates cells, layers of cells, or organs.

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Almost one third of kidney donation candidates are incompatible (HLA and/or ABO) with their directed recipient. Kidney paired donation allows potential donors to be exchanged and gives access to a compatible kidney transplant. The Bioethics Law of 2011 authorised kidney paired donation in France with reciprocity between 2 incompatible "donor-recipient" pairs.

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