Publications by authors named "O Barutcu"
Article Synopsis
- * Researchers treated Wistar dams with VPA to investigate behavioral and neurological changes in their male offspring, which exhibited impairments in social interaction, sensorimotor coordination, and synaptic activity measured by fEPSP.
- * Findings indicated that while the overall metaplastic response was similar between VPA-treated and control animals, key autism-related gene expressions were significantly reduced in the offspring of VPA-treated rats, suggesting a potential adaptation mechanism in response to disrupted gene expression.
Background: In our research, we examined how the induction of long-term potentiation (LTP) in the hippocampus of hypothyroid rats afects the mRNA levels of several proteins involved with neurodegeneration, including Gsk3, Cdk5, Akt1, Mapt, P35 (Anxa), Capn1, Bace1, and Psen2.
Methods: Wistar-albino rats, consisting of 12 males, were used in the research, and they were separated into 2 groups: control (n=6) and hypothyroidism (n=6). To induce hypothyroidism, propylthiouracil was added to drinking water at a dosage of 20 mg/kg/day.
The aim of this study is to show the relationship between the change in the strengthening of synaptic plasticity and tau phosphorylation and tau-kinases and phosphatase. The averages of the field excitatory-postsynaptic potential (fEPSP) and population spike (PS) in the last 5 min were used as a measure of LTP, LTD and MP. Total and phosphorylated levels of tau, kinases and phosphatases were evaluated by western blot and mRNA levels were evaluated by RT-qPCR.
View Article and Find Full Text PDFBackground: The atherogenic index of plasma (AIP) is a biomarker of plasma atherogenicity. Elevated AIP is linked with adverse cardiac events. We sought to examine the association of admission AIP and no-reflow phenomenon (NRP) in acute coronary syndrome (ACS) patient population treated with percutaneous coronary intervention (PCI).
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