Antioxidant Mechanism of Renal and Hepatic Failure Prevention Related to Paracetamol Overdose by the Aqueous Extract of Stem Bark.

Paracetamol is a commonly used analgesic/antipyretic whose long-term intake or overdose is associated with renal and hepatic injuries. The aim of this study was to determine the hepatonephroprotective mechanisms of the aqueous extract of stem bark (AEAASB) on renal and hepatic failure resulting from paracetamol overdose. Forty-five rats were divided into nine groups ( = 5); these were treated once daily for 8 days with 5 ml/kg distilled water (normal, negative, and satellite controls); 0.

Antihistaminergic and Anticholinergic Properties of the Root Bark Aqueous Extract of (Ebenaceae) on Hypersecretion of Gastric Acid Induced in Wistar Rats.

Objective: The objective of this study was to elucidate the antisecretory mechanism of the root bark aqueous extract of (RBAEDM) in Wistar rats. . RBAEDM was tested on three experimental animal models of gastric acid hypersecretion including pyloric ligation (PL), PL with histamine, and carbachol pretreatments.