[Lipid peroxidation and activity of diagnostically important blood enzymes in rats during 35 days head-down suspension].

In the experiment with 35-d head-down suspension of rats concentrations of lipid peroxidation (LPO) products and values of antioxidant defense (AOD) parameters were determined in the lever, skeletal muscles, myocardium, and blood plasma. In addition, activity of 11 plasma enzymes characteristics of these tissues was evaluated. LPO was found to be activated in the lever, myocardium and skeletal muscles in the first and 4-5 weeks of suspension.

[Use of bicycle ergometry test for studying metabolism in women during long-term hypokinesia].

Studies performed under conditions of a 120-day HDT in the female human subjects demonstrated that out of 20 biochemical parameters of the blood characterizing the carbohydrate and lipid exchange only 14 indices changed significantly during hypokinesia. As this takes place, the maximum number of changes was revealed with the help of the graded physical load test (GPL-test) and only in case of 9 indices the alterations were found at rest. Physical loads which have been used during HDT as the preventive measures had no effect only on insignificant part of metabolic shifts such as hypokinesia-associated increase of an activity of blood lactate dehydrogenase and relative content of phosphatidylcholine as well as an increased blood content of phosphates and decreased relative portion of phospholipids which also revealed with the aid of GPL-test.

[Metabolism, intensity of lipid peroxidation and the antioxidant defense system in humans during chamber experiments with long-term isolation].

Blood biochemical parameters of lipid, protein, carbohydrate and energy metabolism were measured in a 135-day chamber experiment. Also, dynamics of the intensity of lipid peroxidation and status of the antioxidant defence system were evaluated. Results of the investigation showed that extended chamber isolation led to modifications of several biochemical parameters including hemoglobin, bilirubin, cholesterol and its fractions, elevated transaminase activity which are typical for long-term space mission.

[Lipid peroxidation and activity of diagnostically significant enzymes in cosmonauts after flights of various durations].

Concentrations of the products of peroxide oxidation of lipids (POL), indices of the system of antioxidant defence (SAD), and the activity of 13 diagnostically significant organic/tissue specific enzymes (DSE) were determined in blood serum of cosmonauts who had participated in short (5-9 days, n = 8), long (125-179 days, N = 15), and superlong (241-366 days, n = 5) missions. To feature an interrelation of the indices under study, the canonical correlation analysis of a set of POL and SAP parameters and DSE activity was performed. Compared with pre-flight values, changes in the POL and SAP parameters were significant in serum only after the long-duration missions.