Cementless revision total hip arthroplasty without allograft in severe proximal femoral defects.

This study evaluates the difficult reconstructive challenge of severe proximal femoral bone loss. We present intermediate-term results of 46 hips with extensive proximal femoral bone loss that underwent revision total hip arthroplasty using cementless distal fixation without supplemental allograft. All were evaluated with the Harris hip score at a minimum of 2 years.

Unicompartmental knee arthroplasty: long-term success in middle-age and obese patients.

The purpose of this study is to report long-term results of unicompartmental knee arthroplasty (UKA) in general and specifically to address the results in middle-age and obese patients. One hundred consecutive medial compartment UKAs performed in 82 patients between 1974 and 1999 were reviewed. Survivorship analysis and Knee Society scores were compiled and stratified based on age at the time of surgery, gender, and body habitus.

Biomechanical testing of cadaveric specimens: importance of bone mineral density assessment.

The bone density of cadaveric specimens is highly variable and has a significant effect on the results of biomechanical testing but it is not often assessed before testing is performed in the lab. Bone mineral density (BMD) tests such as dual X-ray absorptiometry (DXA) are widely available, easy to perform and correlate highly and significantly with bone strength in many modes of failure. We present the results of two different studies performed on cadaveric foot and ankle specimens.

Lumbar spinal fusion using recombinant human bone morphogenetic protein in the canine. A comparison of three dosages and two carriers.

Study Design: A randomized, prospective and controlled animal study.

Objective: To evaluate lumbar spinal fusion using recombinant human bone morphogenetic protein 2 in a canine model.

Summary Of Background Data: Spinal fusion using autogenous bone grafting is associated with donor site morbidity and a nonunion rate of 5% to 35%.

Safety of recombinant human bone morphogenetic protein-2 after spinal laminectomy in the dog.

Study Design: This was a randomized, blinded trial of the safety of the application of recombinant human bone morphogenetic protein (rhBMP)-2 or autologous bone graft onto a laminectomy defect of the dog in the presence or absence of a dural membrane puncture.

Objective: To test the safety of rhBMP-2 in an application in which direct contact of the material with neural tissue occurs.

Summary Of Background Data: Application of rhBMP-2 in laboratory animals stimulates local bone formation to effect spinal fusion and healing of segmental bone defects.