Publications by authors named "O B Smeland"
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.
View Article and Find Full Text PDFThe observation that the risk of developing Alzheimer's disease is reduced in individuals with high premorbid cognitive functioning, higher educational attainment, and occupational status has led to the 'cognitive reserve' hypothesis. This hypothesis suggests that individuals with greater cognitive reserve can tolerate a more significant burden of neuropathological changes before the onset of cognitive decline. The underpinnings of cognitive reserve remain poorly understood, although a shared genetic basis between measures of cognitive reserve and Alzheimer's disease has been suggested.
View Article and Find Full Text PDFArticle Synopsis
- The study highlights the extensive overlap between anxiety disorders (ANX) and major depression (MD), suggesting that most genetic analyses fail to account for this comorbidity, potentially skewing results.
- The research objective is to clarify the genetic and causal relationships between ANX and MD by performing disorder-specific analyses using data from large cohorts like the UK Biobank and Norwegian MoBa.
- Findings show that ANX and MD have a lower genetic correlation when considered separately (0.53) compared to when they are comorbid (0.90), along with evidence of bidirectional causality in comorbid cases, indicating more complex interactions than previously understood.
Background: Genetics has the potential to inform biologically relevant drug treatment and repurposing which may ultimately improve patient care. In this study, we combine methods which leverage the genetics of psychiatric disorders to prioritize potential drug targets and compounds.
Methods: We used the largest available genome-wide association studies, in European ancestry, of four psychiatric disorders [i.
Article Synopsis
- Cognitive impairment is common in individuals with epilepsy, and this study explores the genetic links between different epilepsy subtypes and cognitive ability, revealing that genetic factors play a significant role.
- Researchers analyzed data from 269,867 individuals regarding cognitive ability and 27,559 cases of common epilepsies, using various statistical tools to identify the genetic variants involved.
- The findings indicate that cognitive ability has a much larger number of genetic variants compared to epilepsy types, and they identified 66 genetic loci shared between cognitive function and different epilepsy subtypes, suggesting important gene expressions in brain regions affected by both conditions.