Publications by authors named "O B Navti"

Venous thrombosis and thromboembolism (VTE) remain the leading cause of direct maternal deaths, occurring within 42 days of the end of pregnancy in the UK. Pregnancy is associated with an overall 10-fold higher incidence of VTE than in the non-pregnant state and has been reported to reach up to 30-fold higher in the puerperium. This increased risk is further exacerbated by maternal obesity in a relationship that appears to be proportional with increasing Body Mass Index (BMI).

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Since first reported in December 2019 in Wuhan, China, COVID-19 caused by Severe Acute Respiratory Syndrome (SARS) Corona virus2 (SARS CoV-2) quickly spread to become a pandemic that has caused significant morbidity and mortality. The rapidity of the spread of the virus and the high mortality at the outset threatened to overwhelm health systems worldwide, and, indeed, this significantly impacted maternal health, especially since there was minimal experience to draw from. Experience with Covid 19 has grown exponentially as the unique needs of pregnant and labouring women with COVID-19 infection have become more evident.

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Human papilloma viruses (HPV) are small epitheliotropic DNA viruses, of which there are 200 genotypes, 40 of which are known to cause genital infections and are also oncogenic. HPV is the most common sexually transmitted infection. Clinical features vary from asymptomatic (identified at routine cervical cancer screening) to large lesions on the vulva, vagina, cervix and some extragenital sites.

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Article Synopsis
  • Cytomegalovirus (CMV) is a widely prevalent DNA virus, affecting about 83% of the global population, and is the leading cause of congenital infections that can lead to hearing loss, cognitive impairments, and cerebral palsy in newborns.
  • Maternal CMV infection can occur through contact with infected bodily fluids, with serious fetal consequences often linked to infections in early pregnancy (before 20 weeks).
  • Prevention focuses on educating pregnant women about hygiene practices, as current strategies like vaccines and antiviral treatments are not yet proven effective.
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  • - Lymphedema distichiasis syndrome (LDS) is a rare genetic condition leading to lower limb swelling and unusual eyelash patterns, alongside other potential health issues like cleft palates and heart defects.
  • - A study revealed that affected individuals in one family displayed severe kidney anomalies, including hydronephrosis and renal agenesis, suggesting a potential link between the FOXC2 gene mutation and kidney development issues.
  • - The authors recommend that anyone diagnosed with LDS should undergo a kidney ultrasound to check for abnormalities and that prenatal ultrasounds for at-risk pregnancies should look for signs like hydronephrosis, which may indicate LDS.
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