Publications by authors named "O B McManus"
The neurophysiological mechanisms supporting brain maturation are fundamental to attention and memory capacity across the lifespan. Human brain regions develop at different rates, with many regions developing into the third and fourth decades of life. Here, in this preregistered study (https://osf.
View Article and Find Full Text PDFThe microbiological analysis of wastewater samples is increasingly used for the surveillance of SARS-CoV-2 globally. We described the setup process of the national SARS-CoV-2 wastewater-based surveillance system in Denmark, presented its main results during the first year of activities, from July 2021 to June 2022, and discussed their operational significance. The Danish SARS-CoV-2 wastewater-based surveillance system was designed to cover 85 % of the population in Denmark and it entailed taking three weekly samples from 230 sites.
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- Chronic pain from osteoarthritis (OA) is difficult to treat, necessitating new models to understand its biology and develop effective therapies.
- Researchers created an in vitro model using dorsal root ganglion (DRG) sensory neurons sensitized by an inflammatory cocktail called SPARC, showing that these components can lead to pain responses.
- The study involved high-throughput optical electrophysiology to analyze the effects of approximately 3,000 drugs on the OA-SPARC-induced pain phenotype, highlighting the potential of the Raf-MEK-ERK signaling pathway in DRG neurons as a target for new analgesic treatments.
Background: During the early "containment" phase of the COVID-19 response in England (January-March 2020), contact tracing was managed by Public Health England (PHE). Adherence to self-isolation during this phase and how people were making those decisions has not previously been determined. The aim of this study was to gain a better understanding of decisions around adherence to self-isolation during the first phase of the COVID-19 response in England.
View Article and Find Full Text PDFAnalysis of wastewater is used in many settings for surveillance of SARS-CoV-2, but it remains unclear how well wastewater testing results reflect incidence. Denmark has had an extensive wastewater analysis system that conducts 3 weekly tests in ≈200 sites and has 85% population coverage; the country also offers free SARS-CoV-2 PCR tests to all residents. Using time series analysis for modeling, we found that wastewater data, combined with information on circulating variants and the number of human tests performed, closely fitted the incidence curve of persons testing positive.
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