Publications by authors named "O B Dale"
Ethnopharmacological Relevance: Phyllanthus amarus is ethnomedicinally used to treat gallbladder stones, kidney stones and chronic liver diseases. P. amarus is gaining popularity as an ingredient in many botanical dietary supplements.
View Article and Find Full Text PDFAims: To measure all-cause mortality risk after an ambulance-attended non-fatal opioid overdose and associations with number of days following attendance, and individual and clinical characteristics.
Design: A prospective observational study.
Setting: Oslo, Norway.
Article Synopsis
- The study investigated whether genetic variations in the opioid neuroimmunopharmacology pathway affect how cancer patients respond to morphine treatment, analyzing data from 506 patients.
- It found that patients with pain control had lower levels of morphine-3-glucuronide, while those with cognitive dysfunction had higher morphine levels.
- Certain gene variants were associated with reduced odds of experiencing adverse effects and differing responses to morphine, indicating the importance of both pharmacokinetics and genetics in pain management for cancer patients, despite some limitations in the research.
Naloxone is a World Health Organization (WHO)-listed essential medicine and is the first choice for treating the respiratory depression of opioids, also by lay-people witnessing an opioid overdose. Naloxone acts by competitive displacement of opioid agonists at the μ-opioid receptor (MOR). Its effect depends on pharmacological characteristics of the opioid agonist, such as dissociation rate from the MOR receptor and constitution of the victim.
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