Publications by authors named "O Azocar"
Article Synopsis
- Xenophagy is a crucial cellular process where cells target and degrade harmful pathogens like bacteria using autophagosomes and lysosomes.
- The autophagy receptor NDP52 plays a dual role: it helps target pathogens to autophagosomes and also promotes the maturation of these autophagosomes, ensuring proper degradation of the pathogens.
- This study reveals that NDP52’s functions in pathogen targeting and autophagosome maturation are independent but both are essential for effective xenophagy during infections like Salmonella Typhimurium.
Article Synopsis
- - The relationship between autophagy and intracellular pathogens is complex, as autophagy helps fight infections, but many pathogens, like the measles virus, have evolved ways to evade or take advantage of this process.
- - Measles virus infection triggers multiple autophagy signaling events in cells, starting with an initial transient wave linked to the virus receptor CD46 and the protein GOPC, followed by a sustained signaling response that exploits viral replication and cell fusion.
- - This sustained autophagy response allows the measles virus to prevent cell death and enhance viral production while enabling viral proteins to evade degradation, showcasing the virus's ability to manipulate cellular processes for its benefit.
Article Synopsis
- Autophagy is a key defense mechanism that targets intracellular pathogens, but numerous RNA viruses have developed strategies to evade or manipulate this process for their own replication.
- Researchers studied 83 RNA virus proteins and their interactions with 44 human autophagy proteins, finding that the autophagy network is significantly targeted by these viruses.
- The study highlights the role of the immunity-associated protein IRGM in mediating virus-induced autophagy, suggesting that multiple RNA viruses may exploit similar mechanisms to enhance their infectivity.
While the antiviral response during measles virus (MeV) infection is documented, the contribution of the hosting cell type to the type I interferon (IFN-alpha/beta) response is still not clearly established. Here, we report that a signature heterogeneity of the IFN-alpha/beta response according to the cell type. The MeV tropism dictated by the expression of appropriate cellular receptor appeared to be crucial for epithelial cells.
View Article and Find Full Text PDFAutophagy is a highly regulated self-degradative mechanism required at a basal level for intracellular clearance and recycling of cytoplasmic contents. Upon intracellular pathogen invasion, autophagy can be induced as an innate immune mechanism to control infection. Nevertheless, pathogens have developed strategies to avoid or hijack autophagy for their own benefit.
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