Publications by authors named "O Ay"
Organ transplantation practices have witnessed tremendous advances all over the world and in Türkiye in recent years, and the pre-transplantation preparation, operation and postoperative follow-up procedures are being meticulously handled. However, there is very limited information about follow-up processes of pediatric patients with autism spectrum disorder (ASD) undergoing organ transplantation. Furthermore, it is difficult to manage the arduous and long-term care and follow-up processes in ASD cases undergoing organ transplantation.
View Article and Find Full Text PDFEndoscopic clipping of gastrojejunostomy leakage following Whipple procedure: A case report.
World J Gastrointest Surg
September 2024
Article Synopsis
- - Perioperative complications after classic Whipple surgery occur at a rate of about 40%, with delayed gastric emptying and pancreatic fistula being common, while gastrojejunostomy (GJ) leakage is rare.
- - A case report focused on a 71-year-old male who developed a GJ leak post-surgery, highlighting the use of vacuum therapy and endoscopic intervention to manage the leak, resulting in successful closure with titanium clips.
- - The literature indicates GJ leakage occurs in 0.54% of Whipple surgeries, with an average duration of symptoms from 4 to 34 days; this case marks the first documentation of endoscopic treatment for such leaks.
Article Synopsis
- The study investigates how fatty acid metabolism genes affect milk production traits in Jersey cows, focusing on identifying effective genetic markers.
- The researchers compiled data on milk traits from multiple lactations, genotyped key genes, and analyzed the relationship between genetics and milk output using statistical models.
- Findings indicate significant impacts of specific genes on milk yield and fat production, along with novel interactions that highlight the GGAAGG haplotype as a potential marker for assessing milk fat content.
Article Synopsis
- Langerhans cell Histiocytosis (LCH) and Erdheim-Chester disease (ECD) are linked to certain genetic mutations and pose a heightened risk for neurodegeneration, revealing microglia mutant clones in patients' brains.
- These mutant clones lead to symptoms like microgliosis and neuronal loss, notably affecting specific brain regions, with symptoms correlating to the disease's duration and the size of these clones.
- Research suggests that targeting these mutant microglia with a CSF1R-inhibitor could prevent neuronal loss, presenting a potential new treatment option distinct from current MAPK inhibitors.
Article Synopsis
- Epithelial ovarian cancer (EOC) is a highly deadly gynecological cancer, but recent studies have shown that cytokine-induced memory-like (CIML) natural killer (NK) cells can effectively target EOC cells and enhance immune responses.
- The research indicates that CIML NK cells not only increase activation receptor expression but also improve antitumor effects when engineered with a chimeric antigen receptor (CAR) aimed at mesothelin (MSLN) found on EOC cells.
- These CAR-modified CIML NK cells significantly inhibited tumor growth and metastasis in animal models, suggesting they could be a promising new treatment approach for EOC patients.