A comparison between the localization of lung tumors in uranium miners and in nonminers from 1947 to 1991.

Background: Lung cancer was noted to be increased in cigarette smoking miners and nonminers. Carcinogen particulates deposit differentially in the central, middle, and peripheral zones of the bronchial tree depending on the size of the particle. The object of this study was to evaluate the incidence of tumors; their cell types; and the relationship of particulate size to their position in the bronchial tree.

Reproducibility of major diagnoses in a binational study of lung cancer in uranium miners and atomic bomb survivors.

A binational panel of four Japanese and four American pathologists examined 208 pulmonary neoplasms, according to the World Health Organization (WHO) recommendations, second edition, for the histologic typing of lung tumors. The study design included independent evaluations by pathologists working alone, followed by group reviews. The individual evaluations, and their implications for reproducibility of the WHO recommendations, are reported.

Radiation-associated lung cancer: a comparison of the histology of lung cancers in uranium miners and survivors of the atomic bombings of Hiroshima and Nagasaki.

A binational panel of Japanese and American pulmonary pathologists reviewed tissue slides of lung cancer cases diagnosed among Japanese A-bomb survivors and American uranium miners and classified the cases according to histological subtype. Blind reviews were completed on slides from 92 uranium miners and 108 A-bomb survivors, without knowledge of population, sex, age, smoking history, or level of radiation exposure. Consensus diagnoses were obtained with respect to principal subtype, including squamous-cell cancer, small-cell cancer, adenocarcinoma, and less frequent subtypes.

The changing pattern of lung carcinoma.

In a study of 505 cases of lung carcinoma from a period in which there was a significant change in tobacco-smoking habits, a dramatic shift in the histologic type and location of the lung tumors was observed. Peripheral tumors, found in 30.7% of the carcinomas occurring before 1978, were found in 42% of the carcinomas from 1986 to 1989.

Histologic changes in the urinary bladder in relation to cigarette smoking and use of artificial sweeteners.

A total of 6503 sections of urinary bladder epithelium from 282 subjects were examined in random order, and histologic alterations, particularly the number of cell rows and the presence and extent of cells with atypical nuclei, were recorded. Cases were either individuals who had never smoked or who had smoked cigarettes. Microscopic slides with cells having 50% or more atypical nuclei were found in 4.