exploration and molecular dynamics of deleterious SNPs on the human TERF1 protein triggering male infertility.

By limiting chromosome erosion and end-to-end fusions, telomere integrity is critical for chromosome stability and cell survival. During mitotic cycles or due to environmental stresses, telomeres become progressively shorter and dysfunctional, thus triggering cellular senescence, genomic instability and cell death. To avoid such consequences, the telomerase action, as well as the Shelterin and CST complexes, assure the telomere's protection.

Essential oils from genus: Traditional uses, chemical composition, toxicology, and health benefits.

The genus belongs to the Amaranthaceae family and is known for its many health benefits. Therefore, it is commonly available worldwide and includes more than 47 species, five species have been mainly reported, and has been one of the most widely used plants for thousands of years as a remedy for a wide range of ailments. In recent investigations, the essential oils of the genus have been examined for their antibacterial, antioxidant, and antiviral properties related to specific components such as terpenoid compounds that exhibit pharmacological activity.

Reactive oxygen species in reproduction: harmful, essential or both?

The process of embryonic development is crucial and radically influences preimplantation embryo competence. It involves oocyte maturation, fertilization, cell division and blastulation and is characterized by different key phases that have major influences on embryo quality. Each stage of the process of preimplantation embryonic development is led by important signalling pathways that include very many regulatory molecules, such as primary and secondary messengers.

[Effects of nicardipine on electrophysiologic alterations and enzyme leakage induced in vitro in the guinea pig].

Ventricular strips of guinea-pig left myocardium were placed in a special tissue bath bisected by a thin membrane latex. One of the two compartments was flowed during 2 hours with modified Tyrode's solution in order to mimic the in vivo ischemia-induced effects. Replacement in standard conditions during 30 minutes was considered as representative of ischemic heart reperfusion.