p53 gene alterations in special types of breast carcinoma: a molecular and immunohistochemical study in archival material.

The p53 locus on the short arm of chromosome 17 at 17p13.1 was examined for small genomic deletions and mutations in 23 formalin-fixed, paraffin-embedded cases of special types of breast carcinoma (six medullary, seven apocrine, five differentiated tubular, and five papillary). p53 mutations in the evolutionarily conserved exons 5-9 were detected in 11 cases (four apocrine, two papillary, two medullary, and three differentiated tubular), using the novel non-radioactive PCR-based Hydrolink mutation detection enhancement (MDE) method, and confirmed by direct sequencing of the PCR products.

Multicentricity in breast cancer. A study of 366 cases.

A total of 366 consecutive modified radical mastectomy specimens were studied for determination of multicentricity. The authors found that 187 samples (49.1%) were multicentric.

Megalomastia: histological, histochemical and immunohistochemical study.

Megalomastia is a rare entity characterized by an uncommon enlargement of both breasts. Unilateral megalomastia is extremely rare. The purpose of this study was to collect information concerning the history of patients with this condition and to investigate its histology in order to outline the profile of this peculiar entity.

Tubal conjoined twin pregnancy.

A unique case of tubal conjoined twin pregnancy is reported. The embryos presented a lateral type of conjunction, which also is extremely rare, and were classified as symmetrical iliothroacopagus conjoined twins.

Fibrocystic disease of the breast and HLA antigens.

One hundred and ten patients with fibrocystic disease of the breast and 200 controls were HLA typed with a panel of 100 antisera for A and B locus. The main finding was the decreased frequency of BW35 antigen among patients compared to the controls. The difference remained significant in patients with the fibrous type of the disease and in patients of the nulliparous group.