[Strategic analysis and the drug industry].

During the postwar decades, the quasi-spontaneous growth permitted less rigorous management than that of today in terms of the development of enterprises. The choice was made in a more or less well-considered way and often by 'feeling'. The economic upheaval that followed the oil crises, the acceleration of technological discoveries and their practical applications and the speeding up of the dissemination of information have imposed a new way of strategic decision making on society.

[The rational basis for the short-, medium-, and long-term evolution of the pharmaceutical industry].

In the last few years, a worldwide reorganization affecting the entire pharmaceutical industry has begun and is now accelerating. This intense trend of mergers, acquisitions, market entires++ and exits, reorientation and diversification reflects a new environment. This article sets out to explain the reasons behind this inescapable and rapid evolution.

Antioxidant micronutrients and childhood malignancy during oncological treatment.

Serum antioxidant vitamins A (retinol) and E (alpha-tocopherol), beta-carotene, zinc, and selenium, and cholesterol and related proteins for 170 children with newly diagnosed malignancy were measured at diagnosis and 6 months after initiation of treatment, and compared with those of 632 cancer-free controls. Incident cancer cases and controls were 1-16 years old and recruited between 1986 and 1989. At diagnosis, age- and sex-adjusted serum concentrations of retinol, beta-carotene, zinc, and alpha-tocopherol were significantly inversely associated with cancer.

Assessment of serum antioxidant micronutrients and biochemical indicators of nutritional status in children with cancer in search of prognostic factors.

Serum vitamins A (retinol) and E (alpha-tocopherol), beta-carotene, zinc and selenium, and related proteins for 157 children with newly diagnosed and histologically proven malignancy were compared with those of 632 cancer-free controls. Incident cancer cases and controls were 1-16 years of age and recruited in 1986-1989. Age and sex-adjusted serum concentrations of beta-carotene and alpha-tocopherol were significantly inversely associated with cancer.