Publications by authors named "O Alexander Bell"
Article Synopsis
- Standard first-line chemotherapy for small cell lung cancer (SCLC) combines platinum and etoposide, but while effective, it has limitations like non-durable responses and toxicity.
- Genetic variants in DNA-repair and etoposide metabolism genes were studied in 145 SCLC patients to predict treatment outcomes and safety, with findings linking certain genetic variants to better progression-free survival (PFS).
- The study shows potential markers, like the rs11615 variant, could help personalize treatment, especially in limited-stage SCLC, but more research is needed to confirm these results.
Article Synopsis
- * Research indicates that levels of IRAK-M decrease with age and oxidative stress, with genetic variants linked to a higher risk of developing AMD.
- * Restoring IRAK-M in RPE cells shows promise in protecting against oxidative damage and retinal degeneration, indicating it could be a potential therapeutic avenue for AMD.
Article Synopsis
- Top carnivores, like Tasmanian devils, influence ecological communities through competition and predation, but human habitat disturbance also plays a significant role.
- A study analyzing stable isotopes showed that the decline of Tasmanian devils affected both their own and spotted-tailed quolls' ecological niches, with narrower niches observed in human-altered environments.
- Overall, the research found that anthropogenic disturbances impact mammalian carnivore niches more than the decline of top carnivores themselves, suggesting a complex interplay between these factors.
Article Synopsis
- Deregulation of small non-coding RNAs (sncRNAs) is linked to metastasis in early-stage breast cancer, with RNA sequencing performed on samples from 60 patients.
- Analysis revealed that most sncRNAs were classified as small nucleolar RNA (snoRNA) and small nuclear RNA (snRNA), with no significant expression differences between tumor and sentinel lymph node samples.
- A specific signature of six snoRNAs was identified as potential markers for locoregional metastasis and patient outcomes, highlighting the need for further research to validate these findings in larger patient groups.
The compaction of chromatin is a prevalent paradigm in gene repression. Chromatin compaction is commonly thought to repress transcription by restricting chromatin accessibility. However, the spatial organisation and dynamics of chromatin compacted by gene-repressing factors are unknown.
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