Purification and Fractionation of Lignin via ALPHA: Liquid-Liquid Equilibrium for the Lignin-Acetic Acid-Water System.

In order to effectively practice the Aqueous Lignin Purification with Hot Agents (ALPHA) process for lignin purification and fractionation, the temperatures and feed compositions where regions of liquid-liquid equilibrium (LLE) exist must be identified. To this end, pseudo-ternary phase diagrams for the lignin-acetic acid-water system were mapped out at 45-95 °C and various solvent: feed lignin mass ratios (S : F). For a given temperature, the accompanying SL (solid-liquid), SLL (solid-liquid-liquid), and one-phase regions were also located.

Assessment of Drug History Information in Referral Letters to the Antiretroviral Therapy Outpatient Specialist Clinic of a Federal Teaching Hospital in Ilorin.

Background: The drug use history of a patient is an essential component of a referral letter to a specialist clinic. It guides and enables appropriate patient management while improving the quality of care rendered. There is insufficient data regarding the quality of drug history information in referral letters in this setting.

Combined Intranasal Insulin/Saxagliptin/Metformin Therapies Ameliorate the Effect of Combined Oral Contraceptive- (COC-) Induced Metabolic Syndrome (MetS) with a Major Target on Glucose Metabolism in Adult Female Wistar Rats.

Objective: To evaluate the effect of the chronic use of combined oral contraceptives (COCs: ethinyl estradiol and levonorgestrel) on the indices of metabolic syndrome in adult female Wistar rats and possible therapeutic management.

Materials And Methods: 64 female Wistar rats received either distilled water, norethindrone (NOR), COC, intranasal insulin (INI), metformin (MET), saxagliptin (SAX), INI+MET, and INI+SAX. After 8 weeks of exposure to COC, the animals were sorted into the therapeutic groups.

Therapeutic Potentials of Selected Antihypertensive Agents and Their Fixed-Dose Combinations Against Trastuzumab-Mediated Cardiotoxicity.

Trastuzumab () is useful in the clinical management of HER2-positive metastatic breast, gastric, and colorectal carcinoma but has been limited by its off-target cardiotoxicity. This study investigates the therapeutic potentials of 0.25 mg/kg/day amlodipine, 0.