Publications by authors named "O Aboubakr"
Article Synopsis
- Grade 3 meningiomas are rare and linked to high morbidity and mortality, but the effects of surgical resection and radiation therapy on patient outcomes are still debated.
- A study was conducted on 65 patients with de novo anaplastic meningiomas, revealing a median progression-free survival of 23 months and an overall survival of 2 years, with certain treatments showing significant impact.
- The combination of gross-total resection and adjuvant radiotherapy improved progression-free survival, while tumor grade and age at diagnosis also affected outcomes.
CIC fusions have been described in two different central nervous system (CNS) tumor entities. On one hand, fusions of CIC or ATXN1 genes belonging to the same complex of transcriptional repressors, were reported in the CIC-rearranged, sarcoma (SARC-CIC). The diagnosis of this tumor type, which was recently added to the World Health Organization (WHO) Classification of CNS tumors, is difficult mainly because the data concerning its histopathology (as compared to its soft tissue counterpart), immunoprofile, and clinical as well as radiological characteristics are scarce in the literature.
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- The study focused on glioblastoma, IDH-wildtype, examining survival rates and factors influencing long-term survival in patients diagnosed between 2000 and 2021.
- The median overall survival was found to be 11.2 months, with only 17.6% of patients surviving 2 years and a mere 2.2% surviving 5 years.
- Two key factors for improved survival included receiving standard combined chemoradiotherapy and having a methylated O6-methylguanine-DNA methyltransferase promoter, along with age and specific imaging characteristics at diagnosis.
Background And Objectives: Epilepsy is a common comorbidity of brain tumors; however, little is known about the prevalence, onset time, semiology, and risk factors of seizures in primary CNS lymphoma (PCNSL). Our objectives were to determine the prevalence of epilepsy in PCNSL, to identify factors associated with epilepsy, and to investigate the prognostic significance of seizures in PCNSL.
Methods: We performed an observational, retrospective single-center study at a tertiary neuro-oncology center (2011-2023) including immunocompetent patients with PCNSL and no history of seizures.