METHIONINE SULFOXIDE REDUCTASE A AND NEUROTRANSMISSION ENZYMES IN AUTISM SPECTRUM DISORDER AND DYSTOCIA RELATED AUTISTICS.

Methionine sulfoxide reductase A (MsrA) is an antioxidant enzyme that repairs the oxidation of methionine residues in proteins and free methionine in autism spectrum disorder (ASD). The present study aimed to assess the level of MsrA and neurotransmission enzymes in ASD individuals. Results confirmed that ASD associated with significant (P<0.

Exploring the Role of as an Ointment Formulation in Inducing Wound Healing in Mice Skin.

Background: Natural compounds rich in secondary metabolites have gained attention as alternative therapies for wound healing due to their potential advantages over conventional treatments. Pleurotus ostreatus mushrooms have been identified for their wound-healing properties, including promoting neovascularization, epithelialization, and collagen synthesis.

Material And Methods: This study aimed to investigate the wound-healing properties of different doses of topical Extract of Pleurotus ostreatus in albino mice using an excisional wound model.

Blunted cystine-glutamate antiporter function in the nucleus accumbens promotes cocaine-induced drug seeking.

Repeated cocaine alters glutamate neurotransmission, in part, by reducing cystine-glutamate exchange via system xc-, which maintains glutamate levels and receptor stimulation in the extrasynaptic compartment. In the present study, we undertook two approaches to determine the significance of plasticity involving system xc-. First, we examined whether the cysteine prodrug N-acetylcysteine attenuates cocaine-primed reinstatement by targeting system xc-.

Repeated N-acetylcysteine administration alters plasticity-dependent effects of cocaine.

Cocaine produces a persistent reduction in cystine-glutamate exchange via system x(c)- in the nucleus accumbens that may contribute to pathological glutamate signaling linked to addiction. System x(c)- influences glutamate neurotransmission by maintaining basal, extracellular glutamate in the nucleus accumbens, which, in turn, shapes synaptic activity by stimulating group II metabotropic glutamate autoreceptors. In the present study, we tested the hypothesis that a long-term reduction in system x(c)- activity is part of the plasticity produced by repeated cocaine that results in the establishment of compulsive drug seeking.