Publications by authors named "O Abdelwahab"
Following lower limb amputation residuum skin from the lower leg is used to reconstruct the residual limb. Unlike skin on the sole of the foot (plantar skin), leg skin is not inherently load bearing. Despite this, leg skin is required to be load bearing in the prosthetic socket.
View Article and Find Full Text PDFBackground: Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder, often leading to wheelchair dependence by age 13 with limited treatment options, largely relying on glucocorticosteroids. We assessed the efficacy and safety of vamorolone, a modified synthetic corticosteroid, for DMD.
Methods: We performed a systematic review and meta-analysis using seven databases including prospective studies comparing vamorolone with glucocorticosteroids or placebo in DMD patients.
Carpal tunnel syndrome (CTS) and cardiac amyloidosis (CA) are seemingly disparate medical conditions but may be linked. CTS can be a sign of early CA, and CA can be a hidden cause of heart failure. Therefore, in this systematic review and meta-analysis, we aim to investigate the expected correlation between the occurrence of CTS and CA.
View Article and Find Full Text PDFArticle Synopsis
- The study highlights a lack of available chemical probes for proteins involved in splicing, specifically focusing on a compound called EV96 that selectively reduces a protein called ITK in T cells.
- Researchers found that the effectiveness of EV96 varies depending on the T cell state, which is influenced by different protein turnover rates and how ITK mRNA is spliced.
- The paper presents a comprehensive list of proteins tied to splicing and demonstrates that many splicing factors can be targeted using new chemical strategies, showcasing the potential for splicing-targeted therapies in immune response modulation.