Publications by authors named "O A Zhigulina"
Article Synopsis
- The study aimed to examine the effects of polychemotherapy on cardiovascular biomarkers in 30 patients with newly diagnosed lymphomas, focusing on cardiotoxicity and heart function changes over six months.
- Significant changes were observed in systemic inflammation markers, with C-reactive protein (CRP) and interleukin-6 (IL-6) levels decreasing, while biomarkers like endothelin-1 (ET-1) and ST-2 showed increases that were not statistically significant.
- Despite alterations in diastolic heart function, there were no signs of cardiotoxicity affecting heart muscle contraction, suggesting that polychemotherapy did not adversely impact the patients' systolic function.
Significant advances in timely diagnosis and modern antitumor therapy have led to a considerable increase in the survival rate of cancer patients. On the other hand, the incidence of cardiovascular (CV) diseases and their complications is increasingly growing, including due to side effects of anticancer drugs. CV complications are the most common cause of non-oncological death of cancer patients.
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