Publications by authors named "O A Uspenskaya"
Article Synopsis
- GRN mutations lead to a condition known as FTD-GRN, which causes frontotemporal dementia; PR006 is a new gene therapy aimed at delivering the granulin gene using an adeno-associated virus.
- In initial studies, PR006 showed effectiveness in improving various pathological conditions related to FTD-GRN in animal models and was generally well tolerated in non-human primates.
- An ongoing human trial has reported that PR006 was safe for administration with some transient increases in progranulin levels in cerebrospinal fluid, although some patients experienced treatment-related adverse events, such as CSF pleocytosis and deep vein thrombosis.
Unlabelled: The of the study was to investigate the evolution of the tissue metabolism parameters in the course of the treatment of aggressive periodontitis forms.
Materials And Methods: The paper presents the results of the treatment of 68 patients with chronic generalized periodontitis. The control group comprised 10 healthy individuals.
[Study of clinical and histological features in professional teeth whitening].
Stomatologiia (Mosk)
July 2020
The aim of the study was to study clinical and histological changes in the treatment of discoloration using different systems for professional tooth whitening. The study involved 76 patients. Patients of group 1 had their teeth whitened by the Amazing White Universal Extra photochemical activation system, and group 2 had their teeth whitened by the Beyond Polus system.
View Article and Find Full Text PDFUnlabelled: was to assess correlations between the lipid profile and glycated hemoglobin in order to define their prognostic value as a criterion for the development and progression of type 2 diabetes mellitus (DM2) in individuals with metabolic syndrome and low body mass.
Materials And Methods: The study included the results of examining 50 patients with metabolic syndrome (group 1), 50 with low body mass index (BMI) (group 2), 50 with DM2 (group 3), and 50 apparently healthy people (control group). Biochemical indices of the lipid profile and glycated hemoglobin in the venous blood were assessed using analyzers Clima MC-15 (Spain), BS-200, and BS-200 E (China).