[Pathogenetic importance of helicobacter pylori infection].

H. pylori are etiological factor of human acute and chronic gastritis. Depending on pathogenic factors of microorganism and polymorphism of human genes, chronic gastritis can be a cause for ulcerative enteritis of the duodenum or stomach, gastric adenocarcinoma and MALT-lymphoma development.

[Role of tight junction claudins in the morphogenesis of adenocarcinoma in the presence of Barrett's esophagus].

The purpose of the investigation was to study a role of tight junction (TJ) claudins (CL) in the morphogenesis of adenocarcinoma (AC) in the presence of Barrett's esophagus (BE). The investigation was performed on the specimens obtained from patients, including 41 males and 29 females, aged 16 to 81 years, with gastroesophageal reflux disease (GERD) at endoscopic biopsies and surgery. An immunohistological study was carried out using monoclonal antibodies to Cl 1, 2, 3, 4, 5, and 7 ("Zymed").

[Atrophic gastritis caused by Helicobacter pylori as a precancer disease].

1-3% persons infected with H. pylori develop atrophic gastritis annually. Probability of stomach mucous membrane atrophy in such patients is 50%.

[The role of apoptosis and proliferation of epitheliocytes in morphogenesis of Helicobacter pylori-associated gastritis].

77 patients with chronic Helicobacter gastritis verified endoscopically and exacerbation of duodenal ulcer were examined. H. pylori infection was identified by the rapid ureasa test (CLO-test) and Giemza staining.