Publications by authors named "O A Silas"
Article Synopsis
- Invasive cervical cancer (ICC) is preventable and can be detected early through screening, but women living with HIV often present at advanced stages, leading to higher mortality rates.
- A cohort study in Nigeria enrolled 239 women with confirmed ICC, assessing their HIV status, stages of cancer, and overall survival through various analytical methods.
- Results showed that HIV-positive patients were generally younger, had more advanced stages of ICC at diagnosis, and experienced lower overall survival rates compared to HIV-negative patients.
Introduction: The expansion of antiretroviral therapy (ART) eligibility could lead to earlier initiation of Human Immunodeficiency Virus (HIV) treatment and consequently reduce the risk of HIV-associated Kaposi Sarcoma (KS). We investigated the impact of changes in the Nigerian HIV treatment guidelines on KS incidence among adults enrolled in HIV care in Nigeria.
Methods: We analyzed data of adults who enrolled for HIV care from January 2006 to December 2016 at one of Nigeria's largest HIV treatment centers.
Article Synopsis
- Invasive cervical cancer (ICC) is increasingly prevalent among women with HIV in Nigeria, emphasizing the importance of early detection and treatment to reduce mortality rates associated with advanced stages of the disease.
- A cohort study conducted in two Nigerian hospitals enrolled 239 women diagnosed with ICC, revealing significant differences in age, cancer staging, and survival outcomes between HIV-positive and HIV-negative patients.
- Results indicated that HIV-positive women were younger and presented with more advanced cancer stages, resulting in lower overall survival rates compared to their HIV-negative counterparts.
Background: High risk human papillomaviruses (HR-HPV) have a causal role in cervical oncogenesis, and HIV-mediated immune suppression allows HR-HPV to persist. We studied whether vaginal microbiome community state types (CSTs) are associated with high-grade precancer and/or invasive cervical cancer (HSIL/ICC).
Methods: This was a cross-sectional study of adult women with cervical cancer screening (CCS) at the Jos University Teaching Hospital (JUTH) in Jos, Nigeria, between January 2020 and February 2022.