[Morphological changes of lymphatic system in patients with the lymphedema of lower extremities].

Morphological changes in inguinal lymph nodes, lymphatic collector and subcutaneous space were studied up in patients with the lower extremities lymphoedema. While the lower extremities lymphoedema occurs in inguinal lymph nodes the connective tissues spreading in two variants is observed. In the first one fibroblasts and collagen fibres appears in medullar substance (chordae medullaris and medullar sinuses) and in the second the sclerosis process begins from cortical plateau and paracortical zone.

[Lithium valproate: its neuropharmacological spectrum and effect on transmitter amino acid content of the brain of rats].

The authors studied lithium valproate synthesized at the Institute of Pharmacology, Academy of Medical Sciences of the USSR, and compared it with sodium valproate (depakin, France). It was discovered that like sodium valproate, lithium valproate has a marked anticonvulsant activity, being also effective in experimental seizures induced by bicucullin, exerts a moderate sedative action (potentiation of sodium thiopental and hexenal anesthesia), and a distinct tranquilizing effect in experimental outward inhibition of the conditioned active avoidance response. At the same time the presence in the molecule of lithium ions led to a change in the neurochemical profile of valproate, manifested by an increase in the rat brain content of GABA and glutamate.

[GABA-ergic component in the mechanism of action of the psychostimulant sidnocarb].

The psychostimulant sydnocarb administered in single doses of 15 and 25 mg/kg provokes a dose-dependent decrease in the brain GABA content without affecting the concentration of glutamate and aspartate. This effect remains unchanged but does not get potentiated after combined use of sydnocarb and thiosemicarbazide. During chronic 2-week administration of sydnocarb, a significant reduction in the GABA and aspartate content in the brain is detected.

[Effect of sodium valproate on the mediator amino acid content in the rat brain].

The effect of sodium valproate (200 mg/kg, intraperitoneally) on the content of transmitter amino acids in the large hemispheres, hippocamp and thalamus was studied in experiments on rats. Thirty minutes after the injection no appreciable shifts in the content of GABA or glutamate were recorded in homogenates of these structures. However, this does not exclude the effect of sodium valproate in the dose mentioned on the GABA system at the expense of changes in the compartmentation of GABA.