Differential Molecular Stress Responses to Low Compared to High Doses of Ionizing Radiation in Normal Human Fibroblasts.

Understanding the mechanisms producing low dose ionizing radiation specific biological effects represents one of the major challenges of radiation biology. Although experimental evidence does suggest that various molecular stress response pathways may be involved in the production of low dose effects, much of the detail of those mechanisms remains elusive. We hypothesized that the regulation of various stress response pathways upon irradiation may differ from one another in complex dose-response manners, causing the specific and subtle low dose radiation effects.

Age dynamics of DNA damage and CpG methylation in the peripheral blood leukocytes of mice.

Certain types of DNA damage are known to accumulate with age. Here we present the quantitative data describing the extent of the spontaneous DNA damage in 144 SHK mice of various ages. In each animal, we assessed double strand breaks, single strand breaks and alkali-labile sites, as well as amounts of oxidized purines, oxidized pyrimidines and misincorporated uracils.

Exhaustive data mining comparison of the effects of low doses of ionizing radiation, formaldehyde and dioxins.

Background: Ionizing radiation in low doses is the ubiquitous environmental factor with harmful stochastic effects. Formaldehyde is one of the most reactive household and industrial pollutants. Dioxins are persistent organic pollutants and most potent synthetic poisons effective even at trace concentrations.

[Genetics aspects of different light regime influence on drosophila life span].

It was analyzed the difference of Drosophila life span in strains with low activity of Sod or excision repair enzyme Mus210 (homolog of yeast RAD4 and mammal XPC) in comparison with wild type strain Canton-S in conditions of 24 h and 0 h light. Mutants having low capacity to detoxify free radicals and repair DNA are characterized by stronger difference between life span at 24 h and 0 h light in comparison with wild type strain. Thus the life span increasing in the dark is due to decline of free radical and DNA lesions production.