Publications by authors named "O A Postnikova"

Background: We have recently identified a novel virus detected in alfalfa seed material. The virus was tentatively named alfalfa-associated potyvirus 1, as its genomic fragments bore similarities with potyvirids. In this study, we continued investigating this novel species, expanding information on its genomic features and biological characteristics.

View Article and Find Full Text PDF

Through the recent advances of modern high-throughput sequencing technologies, the "one microbe, one disease" dogma is being gradually replaced with the principle of the "pathobiome". Pathobiome is a comprehensive biotic environment that not only includes a diverse community of all disease-causing organisms within the plant but also defines their mutual interactions and resultant effect on plant health. To date, the concept of pathobiome as a major component in plant health and sustainable production of alfalfa ( L.

View Article and Find Full Text PDF
Article Synopsis
  • The study demonstrates that SARS-CoV-2 enters ARPE-19 ocular cells primarily through caveolae-mediated endocytosis via the LDL receptor (LDLR), rather than through the ACE2 receptor as previously thought.
  • Blocking cholesterol homeostasis with agents like 25-hydroxycholesterol can impede virus entry, but this effect is not due to changes in cholesterol biosynthesis or LXR receptor activation.
  • Inhibition experiments with dynamin and caveolin-1 reveal their critical role in the viral entry process, while clathrin- and flotillin-dependent pathways do not seem to contribute significantly.
View Article and Find Full Text PDF

Background: Seed transmission of plant viruses can be important due to the role it plays in their dissemination to new areas and subsequent epidemics. Seed transmission largely depends on the ability of a virus to replicate in reproductive tissues and survive during the seed maturation process. It occurs through the infected embryo or mechanically through the contaminated seed coat.

View Article and Find Full Text PDF

Here we report an occurrence of Snake River alfalfa virus (SRAV) in Washington state, USA. SRAV was recently identified in alfalfa (Medicago sativa L.) plants and western flower thrips in south-central Idaho and proposed to be a first flavi-like virus identified in a plant host.

View Article and Find Full Text PDF