Very high mutation rate in offspring of Chernobyl accident liquidators.

Exposure to ionizing radiation has long been suspected to increase mutation load in humans. Nevertheless, such events as atomic bombing seem not to have yielded significant genetic defects. The Chernobyl accident created a different, long-term exposure to radiation.

[The role of segmental analgesic mechanisms in the development of silent myocardial ischemia in patients with initial coronary atherosclerosis].

In patients with ischemic heart disease (IHD) with early coronary atherosclerosis the ratio of the myocardial ischemia pain episodes (MIPE) to myocardial ischemia pain-free episodes (MIPFE) is 1:4. In IHD patients, an important role to play in the development of MIPFE has the first segmental link in the analgetic system leading to a segmental rise of the electropain sensitivity threshold. Blockade of alpha 1-adrenoreceptors with prazosinum decreases the activity of analgesic mechanisms and favours transition from MIPFE to MIPE.

The influence of adrenoreactive preparations on clinical and haemodynamic parameters in patients with ischaemic heart disease.

The influence of anaprilin, oxprenolol, nonachlazine, prazosin and levodopa on the clinical course and haemodynamics was investigated in 138 patients with ischaemic heart disease in whom selective coronary angiography had revealed an up to 50 percent stenosis of one of coronary arteries. The clinical picture of IHD patients with a high tolerance of physical exercise was characterized by a preponderance of spontaneous angina pectoris accompanied by painless myocardial ischaemia. A certain role in the genesis of these disturbances is played by the relative increase in the activity of alpha 1-adrenoreceptors and decrease in beta-adrenoreceptor activity.

[Cardiohemodynamics and microcirculation in patients with ischemic heart disease undergoing beta-adrenergic receptor stimulation and blockade].

A study of 76 patients with ischemic heart disease is presented who revealed during coronography stenosis of one-three coronary arteries equalling 50-75% of the vessel lumen. Analysis of the effect of anaprilin and nonachlazin on the clinical course and hemodynamics revealed that in patients with initial coronary atherosclerosis of middle age beta-adrenodependent vasodilation of the coronary arteries decreased. In these patients anaprilin may increase the frequency of attacks of spontaneous stenocardia.