Interventional therapies to relieve chronic deep vein thrombosis (DVT) fail through inability to penetrate, cross, and remove the occlusion. Development of suitable tools requires fundamental understanding of chronic DVT mechanical properties and a reliable model for testing. Female farm swine underwent a novel, endovenous generation of long-segment unilateral iliac vein thrombosis.
View Article and Find Full Text PDFRacist and xenophobic policies in the United States (e.g., family separations and lack of access to protected immigration statuses for undocumented immigrants) have historically excluded immigrants of color from accessing full civil rights, thus contributing to widening racial inequities in the US.
View Article and Find Full Text PDFLight-emitting diodes (LEDs) have revolutionized artificial lighting, but also exposed the detrimental health effects that stem from insufficient exposure to natural light. Human-centric artificial lighting requires both visual quality and circadian lighting performance that mimics daylight's evolving spectral power distribution (SPD). Here, we present a color-tunable LED-based light source that achieves SPDs similar to various conditions of daylight and incandescent lighting over the range of visible wavelengths.
View Article and Find Full Text PDFThe Endoplasmic Reticulum (ER)-resident HSP70 chaperone BiP (HSPA5) plays a crucial role in maintaining and restoring protein folding homeostasis in the ER. BiP's function is often dysregulated in cancer and virus-infected cells, conferring pro-oncogenic and pro-viral advantages. We explored BiP's functions during infection by the Kaposi's sarcoma-associated herpesvirus (KSHV), an oncogenic gamma-herpesvirus associated with cancers of immunocompromised patients.
View Article and Find Full Text PDFSensory processing sensitivity (SPS), linked to processing external and internal stimuli, has drawn attention to its associations with clinical factors, particularly with health-related quality of life (HRQOL) variables. This study examined the relationships among SPS, stress, sleep quality, and HRQOL, establishing an explanation model. Eight hundred adults (M = 26.
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