[An evaluation of the toxicity of manganese and iron in their separate and joint body uptake].

Different effects for the manganese and iron uptake with a drinking water were received. An antagonism and/or synergism of these ions at levels of 1/50 and 1/10 CL50 were noted.

[Study of a series of enzyme systems and ultrastructure of rat liver in iron-manganese poisoning].

During consumption of drinking water containing manganese or combination of iron and manganese several biochemical patterns were altered in animal blood and liver tissue: content of SH-groups, total lipids, activity of alkaline phosphatase, content of cytochromes b5 and P-450 in liver microsomal fractions. Light and electron microscopy showed that local unspecific alterations of hepatocytes structure occurred in liver tissue. Activation of cytochromes in response to administration of the metals appears to involve alterations in phospholipid composition of endoplasmic reticulum.