Investigation of the Peripheral Analgesic Activity of Oxicams and Their Combinations with Caffeine.

Objectives: Therapy of pain syndromes involves exposure to its source, receptors, and peripheral fibers. Treatment of acute pain and inflammation involves the use of nonsteroidal anti-inflammatory drugs and nonnarcotic analgesics. An alternative to obsolete analgesics is combined compositions.

[Polymorphism A1166C of AGTR1 Gene and the State of Intrarenal Blood Flow in Patients with Essential Arterial Hypertension 1-2 Degrees].

Aim: to study relationship between genetic disorders and features of intrarenal blood flow in patients with essential arterial hypertension (AH) of 1-2 degree.

Materials And Methods: We examined 100 patients (60 women, 40 men) aged 35 to 58 years with 1-2‑degree essential arterial hypertension (AH) and chronic kidney disease (CKD) stages I-III. Examination included triplex scanning of renal arteries on the ultrasound scanner Vivid-7 Dimension, genotyping of single-nucleotide polymorphism А1166С of the AGTR1 gene by real time polymerase chain reaction (PCR), estimation of glomerular filtration rate (GFR) using CKD-EPI formula.

[The interrelationship of indices of hemocysteine and genetic polymorphisms conditioning disorders of folates metabolism in healthy population].

The study was carried out to investigate relationship of the level of homocysteine and genetic polymorphisms conditioning disorders of metabolism of folates in healthy population and of various age and gender groups. The study covered 168 donors: 98 males and 70 females. Two gender groups were singled out and in each of them age groups: 18-31, 32-45 and 46-60 years old.

[The active neuroprotective therapy of acute carotid ischemic stroke of moderate severity].

Objective. To evaluate the efficacy of neuroprotective therapy in carotid ischemic stroke. Material and methods.

[Correction of endothelial dysfunction by L-arginine under experimental pre-eclampsia conditions].

The ADMA-like pre-eclampsia in pregnant rats was modeled by daily introduction of L-NAME in a dose of 25 mg/kg for 7 days. L-arginine (200 mg/kg) prevented the development of arterial hypertension and a decrease in placentary microcirculation and microalbuminuria. The possibility of using L-arginine for the prevention of competitive eNOS inhibition by ADMA is discussed.