[Effect of alimentary protein deficiency in the early postnatal period on the function of the immunocompetent system in rats].

The influence of protein deficiency in the early postnatal period on the functional and morphological characteristics of the immunocompetent system was studied in 76 test and 60 control rats, 4 and 12 months after the experiment commencement. It was shown that protein deficiency in the early postnatal period induced shifts in the cellular parameters of the immunologic responsiveness, mainly, producing no significant changes in the nonspecific factors of body defence. The impairing effect of protein deficiency was more manifest at the early steps of the body development.

[Effect of dietary protein deficiency in female rats on the function of the immunocompetent system of their progeny].

The influence of alimentary protein deficiency, during early ontogenesis, on the morphofunctional characteristics of the immunocompetent system was studied in 115 experimental and 60 control female rats, 4 and 12 months after the commencement of the experiment. It was shown that protein deficiency in the period of prenatal ontogenesis induced significant changes in the humoral and cellular values, characterizing immunologic responsiveness and nonspecific resistance of the body, and leads to alteration of the morphological structure of the lymphoid organs. Such changes were also observed in the rats of the second generation, which received full-value food, thus evidencing grave and stable immunologic disorders as the result of protein deficiency during prenatal ontogenesis.

[Various indicators of the state of the body during intravenous feeding with different mixtures].

Experiments lasting 15 days were made on rats fed intravenous isocaloric mixtures of the same composition (amino acids, glucose, fatty emulsion, mineral substances and vitamins), with one of the mixtures containing no fatty emulsion. It was noticed that intravenous feeding resulted in certain changes in body function, being consequent on the process of adaptation. The mixtures with and without fatty emulsion produced the same weight gain.

[Various indicators of renal function in experimental malnutrition].

Study of renal function in rats during long-term choline-protein deficiency has demonstrated the development of renal failure in the late stages of experiments. After the period of recovery all the parameters under study returned to normal, with the exception of blood serum concentration of endogenous creatinine, which in experimental group animals was lower (p less than 0.025) as compared with this indicator in the control.