[Galectines as prognostic factors for the malignant lymphoproliferative diseases].

Galectines are a family of carbohydrate-binding proteins with an affinity for beta-galactosides. Galectines is differentially expressed by various normal and pathological tissues and appears to be functionally polyvalent, with a wide range of biological activity. The intracellular and extracellular activity of galectines has been described.

[Diagnostics, prognosis factors, and treatment of malignant lymphoproliferative disease, Hodgkin Disease].

Data are presented about modern histomorphological, cytological, radiological methods of diagnostics of malignant lymphoproliferative diseases (illness of Hodgkin). Principles and methods of treatment are presented are charts of polychimiotherapy their quality and amount, sequence of realization of radial therapy. Onkomarker being most perspective and studied presently is described, factors of prognosis at non-Hodgkin's malignant lymphadenomas, illness of Hodgkin, - galectin-1, galectin-3.

[ELISA test-kit for herpes 2 serodiagnosis].

To reveal Herpes simplex virus 2 specific IgG and to determine their avidity the ELISA test-kit was constructed using recombinant protein gG2 (PSC SPC Diaproph-Med). Using this test-kit the distribution of specific antibodies with different avidity indexes was investigated in practically healthy donor samples. It is possible to use the mentioned ELISA test-kit for confirmation of primary infection, and also for differentiation of primary infection, chronic disease and virus reactivation.

[Cytochrome P450 2E1 expression in mice liver after exposure to continuous and acute gamma-radiation].

The effect of continuous low-intensity and acute high-intensity ionizing radiation in low and high doses on expression of cytochrome P450 2El (1.14.14.

[Effect of interferonogenic molecular complex of yeast RNA--tilorone on DNA, RNA and protein synthesis in vitro].

In the experiments in vitro using the primary mononuclear cells (MNC) culture of the human peripheral blood the influence of interferonogenic yeast RNA-tilorone molecular complex on the DNA, RNA and protein synthesis was studied. The complex was shown to inhibit the insertion of 3H-thymidine, 3H-uridine and 3H-leucine into DNA, RNA and protein of MNC total pool (by 13, 1 and 40% respectively); that was practically conformed with this synthesis inhibition upon to a natural origin polynucleotide interferon inducers--lariphan (9, 0 and 57% respectively) and ridostin (9, 0 and 56% respectively) action, and at the same time rather less than poly(I)-poly(C) (14, 5 and 62% respectively). In the case of preliminary cell stimulation by the mitogen PHA the complex revealed comitogenic action at a concentration 25 micrograms/ml, that corresponded to optimal for interferonogenesis; the increase of the doses till 100-1000 micrograms/ml lead to in the reversal effect.