Publications by authors named "O A Kurilova"
Article Synopsis
- - The angiotensin-converting enzyme (ACE) plays a key role in regulating blood pressure and is linked to various health conditions, particularly cardiovascular diseases and granulomatous diseases, with elevated levels indicating potential health risks.
- - A new method called ACE phenotyping was used to investigate a specific donor's blood, revealing a unique conformational impairment in ACE, which is found in a small percentage of the healthy population and more frequently in patients with kidney issues.
- - The study linked increased ACE activity and a specific M71V genetic mutation to elevated levels of a natural ACE inhibitor and proposed that monitoring ACE conformational changes could also reflect free bilirubin levels in plasma, which has clinical implications for patient health assessments.
Elevated ACE expression in tissues (reflected by blood ACE levels) is associated with increased risk of cardiovascular diseases and is also a marker for granulomatous diseases. We developed a new approach for characterization of ACE status in the blood-ACE phenotyping and established normal values of ACE levels 50-150% of control pooled plasma. ACE phenotyping was performed in citrated plasma of 120 patients with known interstitial lung diseases.
View Article and Find Full Text PDFWe performed a targeted sequencing of 242 clinically important genes mostly associated with cardiovascular diseases in a representative population sample of 1,658 individuals from the Ivanovo region northeast of Moscow. Approximately 11% of 11,876 detected variants were not found in the Single Nucleotide Polymorphism Database (dbSNP) or reported earlier in the Russian population. Most novel variants were singletons and doubletons in our sample, and virtually no novel alleles presumably specific for the Russian population were able to reach the frequencies above 0.
View Article and Find Full Text PDFBackground: Angiotensin-converting enzyme (ACE) metabolizes a number of important peptides participating in blood pressure regulation and vascular remodeling. Elevated ACE expression in tissues (which is generally reflected by ACE in blood) is associated with increased risk of cardiovascular diseases. Elevated ACE in blood is also a marker for granulomatous diseases.
View Article and Find Full Text PDFPurpose: Cystic fibrosis (CF) is one of the most common monogenic diseases with an autosomal recessive inheritance. Carrier screening leads to a reduction in the number of children born with CF disease. The aim of this study was to develop the custom panel for the diagnosis of heterozygous carriage of polymorphic variants in the gene and to establish their allelic frequencies (AF) in one of the Russian regions where ethnic Russians predominate.
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