[Interrupted alcohol treatment and liver: free radical homeostasis, nitric oxide, adaptive mechanisms].

Alcohol administration can result in liver damage. Reactive oxygen species (ROS), nitric oxide (NO) and their interaction are crucial factors in this process. The aim of work was to investigate, free radical state and mechanisms of adaptation of the antioxidant system (AOS) to stress, caused by interrupted alcohol intake.

Effects of aging and life-prolonging diet on thyroid regulation of protein synthesis.

The effect of thyroxin on the intensity of protein synthesis in rats of different age was studied during natural aging and in rats maintained on a low-caloric diet inhibiting aging. The intensity of protein synthesis decreased and the reaction to hormonal stimulus was absent in animals fed life-prolonging diet.

Lysosomal proteolysis: effects of aging and insulin.

Age-related characteristics of the effect of insulin on the activity of lysosomal proteolytic enzymes were studied. The relationship between the insulin effect on protein degradation and insulin degradation was analyzed. The effect of insulin on the activities of lysosomal enzymes was opposite in young and old rats (inhibitory in 3-month-old and stimulatory in 24-month-old animals).

[Age-related characteristics of experimental hypothyroidism in rats].

The rate of both the synthesis of liver and plasma proteins and RNA-1 and RNA-2 polymerase activities in liver were studied in rats of various ages at experimental hypothyroidism. There has been marked more significant decrease in plasma protein synthesis with age. Both the rate of liver and plasma protein synthesis have been shown to be reduced at experimental hypothyroidism but synthesis of plasma proteins was inhibited to a greater extent.