Immunology of gut microbiome and liver in non-alcoholic fatty liver disease (NAFLD): mechanisms, bacteria, and novel therapeutic targets.

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world. Most important contributors to its development are diet and obesity. Gut microbiome's importance for immune system and inflammatory pathways more widely accepted as an important component in NAFLD and other liver diseases' pathogenesis.

Comparison of pcr diagnostic method and mass spectrometry of microbial markers method as applied to the evaluation of oral microbiota.

Rapid informative methods for assessing the species and quantitative composition of the microflora of the periodontal and oropharyngeal covering tissues are necessary for operative diagnostics, including those of the dentofacial system. The use of classical bacteriological methods, including seeding, incubation, counting and identification of microorganisms takes up to 5 days, resulting in a significant delay in obtaining the necessary information, which makes it difficult to carry out operative treatment measures. Therefore, the search for means and methods of operative microbiological control is urgent.

[Curcumin in the correction of oxidative and immune disorders during exercises].

Oxidative and immune dysfunctions during physical exertion can be associated with a violation of enzyme systems and antioxidant protection, the state of innate and adaptive immunity. This creates the preconditions for their pharmacological correction. of this review is to summarize and analyze modern data on the role of curcumin, one of the components of the extract of turmeric rhizomes (Curcuma longa), in the correction of oxidative stress and immune disorders during physical exertion.

[Changes in the immune and antioxidant status and the role of vitamin D in their correction in older educators.].

The study included 50 women aged 60±1,5 years, teaching for 30±5,5 years at the middle level of a secondary school (grades 5-9) - main group, and 50 non-working women 61,5±1,3 years. The purpose of the study was to study the role of vitamin D in the formation of immunopathogenetic changes from cellular and humoral immune factors, free radical oxidation processes in working teachers and unemployed elderly women and the possibility of correcting the revealed violations with vitamin D subsidy. Before the start of the study, a decrease in the total content of vitamin D was revealed, violation of the functional and metabolic status of immunocytes, an imbalance in the production of Th1/Th2 cytokines, an increase in primary and secondary products peroxidation of the lipid extract of blood plasma, a decrease in the activity of superoxide dismutase and catalase to the main and control groups.

The bioenergetics of COVID-19 immunopathology and the therapeutic potential of biophysical radiances.

In developing an effective clinical tool against COVID-19, we need to consider why SARS-CoV-2 infections develop along remarkably different trajectories: from completely asymptomatic to a severe course of disease. In this paper we hypothesize that the progressive exhaustion and loss of lymphocytes associated with severe stages of COVID-19 result from an intracellular energy deficit in an organism which has already been depleted by preexisting chronic diseases, acute psychological stress and the aging process. A bioenergetics view of COVID-19 immunopathology opens a new biophysical opportunity to enhance impaired immune function via proposed pathways of photomagnetic catalysis of ATP synthesis, regenerative photobiomodulation and the ultrasonic acceleration of cell restructuring.