Intracellularly Biodegradable Polyelectrolyte/Silica Composite Microcapsules as Carriers for Small Molecules.

Microcapsules that can be efficiently loaded with small molecules and effectively released at the target area through the degradation of the capsule shells hold great potential for treating diseases. Traditional biodegradable polyelectrolyte (PE) capsules can be degraded by cells and eliminated from the body but fail to encapsulate drugs with small molecular weight. Here, we report a poly-l-arginine hydrochloride (PARG)/dextran sulfate sodium salt (DEXS)/silica (SiO2) composite capsule that can be destructed in cells and of which the in situ formed inorganic SiO2 enables loading of small model molecules, Rhodamine B (Rh-B).

[The investigation of alpha1-antitripsin, orozomukoid and ceruloplasmin in peripheral blood and oral fluid. Paradontitis is one of more risk factors of cardiovascular diseases].

This article presence the connection between paradontitis and cardiovascular diseases, and definition of the maintenance of acute phase proteins in an oral fluid at patients with acute myocardial infarction is obviously important for clinic. Results of own researches of change of the maintenance of three acute phase proteins: ceruloplasmin, alpha1-antitripsin and orosomucoid in an oral fluid and blood plasma at paradontitis and myocardial infarction allow to consider the paradontitis as one more risk factor of a cardiovascular pathology, except well-known hypertensions, smoking, a diabetes.

[Diagnostic value of the determination of salivary acute-phase proteins in patients with myocardial infarction].

The salivary and plasma levels of acute phase proteins were determined in 59 patients with myocardial infarction (MI). In acute and subacute MI, the content of ceruloplasmin, orosomucoid, and alpha1-antitrypsin increased not only in the plasma, but also in the saliva. A noninvasive procedure was devised to diagnose the termination of an inflammatory process in the necrotic process in MI, which implies the determination of salivary ceruloplasmin, if the latter is less than 106 mg/l, inflammation completeness in the necrotic area is diagnosed.