Publications by authors named "O A Freĭlikhman"
Aim: Comparison of diagnostic capabilities of 2 variants of PCR for detection of Coxiella burneli persistence in dynamics of infectious process in patients with Q fever.
Materials And Methods: 110 samples of clinical material, obtained from patients with Q fever in an endemic region for this infection (Astrakhan region), were studied. The samples were studied in a standard PCR (marker - 16S rRNA gene fragment) and in real-time.
Article Synopsis
- Mutations in the LMNA gene, which produces the lamin A/C protein, are linked to various disorders (laminopathies) primarily affecting mesenchymal tissues like fat, muscle, and bones.
- The study examines how different LMNA mutations (such as G465D, R482L, G232E, R527C, and R471C) impact the differentiation of mesenchymal multipotent stem cells (MMSC) during fat and bone development.
- Results showed that each LMNA mutation uniquely alters gene expression related to differentiation, affecting how effectively MMSC can become fat or bone cells, hinting at a specific relationship between mutations and cell fate outcomes.
We analyzed restriction fragment length polymorphism of lipL32 gene encoding outer membrane protein in three Leptospira genomic species (L. interrogans, L. kirschneri, and L.
View Article and Find Full Text PDF[Improvement of method of Coxiella burnetii detection in biological material based on groEL gene amplification].
Zh Mikrobiol Epidemiol Immunobiol
October 2010
Aim: Improvement of PCR for detection of Coxiella burnetii in field material by development of set of primers for amplification of groEL gene fragment.
Materials And Methods: C. burnetii strains, samples from organs of wild rodents and laboratory animals, blood of healthy donors and laboratory animals.