[Effect of glycerin on the biosynthesis of heliomycin by Streptomyces olivocinereus].

Glycerol as the sole carbon source was added to the medium or biosynthesis of heliomycin by Streptomyces olivocinereus and the effect of its concentration on the culture growth and antibiotic production was studied. The culture growth and the amount of the antibiotic synthesized per 1 unit of the fermentation broth were limited by glycerol added in quantities of 0.05 to 1 per cent.

[L-arabinose control of the formation of heliomycin complex synthesized by Streptomyces olivocinereus].

The unfavourable effect of arabinose on biosynthesis of heliomycin resembled by its outer appearance the "glucose effect", a well known phenomenon relevant to glucose inhibition of the synthesis of catabolic enzymes of other sugars. Arabinose inhibited glycerol utilization by the cells of S. olivocinereus preadapted to it.

[Elaboration of the method of "quiescent cells" for the study of heliomycin-synthesizing system of Streptomyces olivocinereus].

A resting cell procedure was developed for S. olivocinereus. Washed mycelium of S.

[Kinetic aspects of the relation of the growth of the producer and the biosynthesis of heliomycin depending on the carbon source in the medium].

Kinetic parameters of Streptomyces olivocinereus 11-98 growth and biosynthesis of heliomycin were studied. It was shown that carbon sources such as glycerol, mannitol and ramnose were the most favourable for the antibiotic biosynthesis. These carbon sources belonged to the group of substances providing high growth rates of the culture.