Fluorescence of radiation-induced tissue damage.

Purpose: The aim of this study was evaluating changes in the photosensitizer fluorescence in vivo in the radiation-induced damage area in comparison of intact areas with a simultaneous assessment of changes both in blood parameters and in histological data.

Materials And Methods: The study was conducted in white outbred SHK mice (n = 21). Their right hindlimbs were irradiated with a dose of 25 Gy after the intraperitoneal injections of photosensitizer 'Photosens'.

[Increasing the effectiveness of skin cancer T(2-3) N0M0 radiotherapy by use of radiosencibilizers].

The paper presents an attempt to increase the effectiveness of radiotherapy of locally advanced skin cancer by use of radiomodifiers. With this aim the researchers used metronidozol (MZ) and low-intensive laser emission (LILE), whoes radiosensibilizing activity is based on overcoming radioresistance of tumor hypoxic cell fraction. In order to increase MZ concentration in the tumor and eleminate its toxic effect the authors developed a new radiosensibilization technique, implying local use of a drug applicator.

[A comparative analysis of the brain computer tomography in patients with acromegaly before and after gamma-therapy].

The data given in the paper suggest that X-ray computed tomography is highly effective in evaluating the characteristics of pituitary adenomas in acromegaly and in revealing the changes caused in the pituitary adenoma by gamma-ray teletherapy. The use of brain computed tomography yielded data on the main X-ray criteria to be used in the follow-up of patients undergone radiation therapy for acromegaly.

[An experience with combined therapy of radiation and Bonephos for osteolytic metastases of breast cancer].

A new procedure of conservative treatment (radiation + benephos) is suggested to improve the quality of life of cancer patients with osteolytic metastases. Radiation regimen, dosage, benephos administration methods and characteristics of combined therapy are discussed. The procedure was tested in the course of the treatment of 21 breast cancer patients with osteolytic metastases.