[Necrotizing fasciitis: pathophysiological and clinical aspects of the problem].

The data of literature and results of treatment of 17 patients with necrotizing fasciitis are analyzed. Original conception of pathogenesis based on thrombosis of microcirculatory vessels of superficial fascia is described. Endotoxemia manifested with clinical picture of sepsis and septic shock.

[Necrotizing fasciitis].

An experience with treatment of four patients with necrotizing fasciitis (NF) and a review of literature were used to characterize this rare but dangerous for life disease, The pathogen of NF is a hemolytic group A streptococcus and anaerobes. The mechanism of the development of fasciitis is based on impairments in the microcirculatory bed due to the action on the cytokine endothelium. Rapidly progressing necrosis of fasciae results in a number of complications.